Symbol
Name
ID

Dock8
dedicator of cytokinesis 8
MGI:1921396

Phenotype annotations related to immune system

Darker colors indicate more annotations

Human Phenotypes

Increased circulating IgE level

Increased circulating IgG level

Decreased circulating total IgM

Autoimmune hemolytic anemia

Eosinophilia

Neutropenia

Neutropenia in presence of anti-neutropil antibodies

B lymphocytopenia

Decreased proportion of CD4-positive helper T cells

Reduced proportion of CD4-negative, CD8-negative, alpha-beta regulatory T cells

T lymphocytopenia

Reduced natural killer cell count

Decreased FOXP3-expressing T cell count

Autoimmune thrombocytopenia

Recurrent sinusitis

Allergic rhinitis

Conjunctivitis

Lymphadenopathy

Splenomegaly

Eosinophilic infiltration of the esophagus

Colitis

Recurrent gastroenteritis

Hepatitis

Sclerosing cholangitis

Chronic otitis media

Recurrent otitis media

Thyroiditis

Glomerulonephritis

Membranous nephropathy

Cutaneous abscess

Inflammatory abnormality of the skin

Crusting erythematous dermatitis

Eczematoid dermatitis

Atopic dermatitis

Erythroderma

Psoriasiform dermatitis

Recurrent skin infections

Recurrent bacterial skin infections

Myositis

Osteomyelitis

Pneumonia

Recurrent pneumonia

Autoimmunity

Anti-glutamic acid decarboxylase antibody positivity

Anti-liver cytosolic antigen type 1 antibody positivity

Anti-thyroid peroxidase antibody positivity

Insulin receptor antibody positivity

Immune dysregulation

Allergy

Drug allergy

Food allergy

Anaphylactic shock

Asthma

Sepsis

Recurrent infections

Recurrent bacterial infections

Recurrent fungal infections

Onychomycosis

Recurrent candida infections

Recurrent respiratory infections

Recurrent sinopulmonary infections

Recurrent viral infections

Severe infection

Severe viral infection

Meningitis

Molluscum contagiosum

Disseminated molluscum contagiosum

Disease(s) Associated with DOCK8

atopic dermatitis

hyper IgE recurrent infection syndrome 2

immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome

Mouse Phenotypes

abnormal cellular extravasation

decreased T cell proliferation

abnormal B cell differentiation

abnormal T cell differentiation

abnormal CD4-positive T cell differentiation

abnormal CD8-positive, alpha-beta T cell differentiation

decreased germinal center B cell number

decreased B-1 B cell number

decreased marginal zone B cell number

absent marginal zone B cells

increased central memory CD4-positive, alpha-beta T cell number

increased effector memory CD4-positive, alpha-beta T cell number

decreased CD4-positive, alpha-beta T cell number

increased CD4-positive, alpha-beta T cell number

increased central memory CD8 positive, alpha-beta T cell number

increased effector memory CD8-positive, alpha-beta T cell number

decreased CD8-positive, naive alpha-beta T cell number

decreased CD8-positive, alpha-beta T cell number

decreased T cell number

decreased activated T cell number

decreased spleen germinal center size

decreased IgG level

decreased IgM level

decreased follicular dendritic cell number

abnormal dendritic cell physiology

abnormal humoral immune response

impaired humoral immune response

decreased susceptibility to experimental autoimmune encephalomyelitis

Availability

Mouse Genotype

Dock8^cpm/Dock8^cpm

Dock8^m1Anu/Dock8^m1Anu

Dock8^m1Btlr/Dock8^m1Btlr

Dock8^m2Anu/Dock8^m2Anu

Dock8^M2Btlr/Dock8^M2Btlr

Dock8^M3Btlr/Dock8^M3Btlr

Dock8^m4Btlr/Dock8^m4Btlr

Dock8^pri/Dock8^pri

Dock8^tm1Ysfk/Dock8^tm1Ysfk

Dock8^cpm/Dock8^pri

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/23/2024 MGI 6.23